Functional responses corresponded with structural changes through reductions in open field exploration and impairments in spatiotemporal gait parameters. Like patients, pigs showed a reduction in circulating lymphocytes and a surge in neutrophils and band cells. Stroke negatively impacted white matter integrity with decreased fractional anisotropy values in the internal capsule. At 24 h post-stroke, magnetic resonance imaging revealed a decrease in ipsilateral diffusivity, an increase in hemispheric swelling resulting in notable midline shift, and intracerebral hemorrhage. Stroke was induced by middle cerebral artery occlusion in Landrace pigs. In this study, the evolution of acute ischemic tissue damage, immune responses, and functional deficits were further characterized. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ischemic stroke model. The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics.
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